For those traveling north on I-65:
Take exit 133b, the westbound Eastern Parkway exit. You will turn right at the bottom of the exit ramp, and curve right immediately. Travel for approximately 1 block and turn right onto Eastern Parkway. You will immediately pass under I-65.
Follow Eastern parkway through a jog right, over a bridge, and a jog left, until Eastern dead-ends into 3rd Street. (3rd Street is the second traffic light on Eastern Parkway).
Turn right onto 3rd Street and take the first right into the circle drive at the main gates of the University. About 1/3 of the way around the drive is a Visitor Information Center followed by the entrance to a parking lot. Drive up to the window of the Visitor Information Center and obtain a parking permit. They will tell you where to park and will give you directions to the Natural Sciences Building.